By Xian Ming Zeng
Interactions among drug particulates are the most important in settling on drug dispersion and deaggregation, and eventually supply potency. This booklet combines rules validated in floor and colloidal chemistry with pharmaceutical powder expertise. It discusses a few of the elements affecting particulate interactions, and particle-fluid interplay within the breathing tract. The publication then is going directly to severely evaluation the various reports performed in dry powder formula improvement, and at last, it proposes attainable suggestions in enhancing DPI potency. the vast majority of those rules are appropriate to different pharmaceutical sturdy dosage kinds (e.g. drugs and capsules).
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Extra info for Particulate Interactions in Dry Powder Formulations for Inhalation
And depending on the nature of the latter either positive or negative charges can be produced. Most pharmaceutical excipients, including lactose, are charged electronegatively following contact with a glass surface, which usually acts as an electron-donor (Staniforth and Rees, 1982a) whereas such excipients were found to become electropositive 36 ■ INTERPARTICULATE FORCES IN PHARMACEUTICAL POWDERS after contact with a polyethylene surface. Both salbutamol sulphate and lactose particles became positively charged after contact with plastic containers, whereas following contact with a metal surface, lactose particles adopted an electronegative charge whilst salbutamol sulphate became positively charged.
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Particulate Interactions in Dry Powder Formulations for Inhalation by Xian Ming Zeng