Download e-book for iPad: Particulate Interactions in Dry Powder Formulations for by Xian Ming Zeng

By Xian Ming Zeng

ISBN-10: 0748409602

ISBN-13: 9780748409600

Interactions among drug particulates are the most important in settling on drug dispersion and deaggregation, and eventually supply potency. This booklet combines rules validated in floor and colloidal chemistry with pharmaceutical powder expertise. It discusses a few of the elements affecting particulate interactions, and particle-fluid interplay within the breathing tract. The publication then is going directly to severely evaluation the various reports performed in dry powder formula improvement, and at last, it proposes attainable suggestions in enhancing DPI potency. the vast majority of those rules are appropriate to different pharmaceutical sturdy dosage kinds (e.g. drugs and capsules).

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And depending on the nature of the latter either positive or negative charges can be produced. Most pharmaceutical excipients, including lactose, are charged electronegatively following contact with a glass surface, which usually acts as an electron-donor (Staniforth and Rees, 1982a) whereas such excipients were found to become electropositive 36 ■ INTERPARTICULATE FORCES IN PHARMACEUTICAL POWDERS after contact with a polyethylene surface. Both salbutamol sulphate and lactose particles became positively charged after contact with plastic containers, whereas following contact with a metal surface, lactose particles adopted an electronegative charge whilst salbutamol sulphate became positively charged.

S. V. (1980) On the influence of molecular forces on the deformation of an elastic sphere and its sticking to a rigid plane. J. Colloid. Interf. Sci. 77, 91–101. , LOCKE, B. B. (1992) Effect of geometry on particle adhesion. Aerosol. Sci. Tech. 17, 105–118. P. and ZOGRAFI, G. S. (1967) The flow properties of powders. H. E. (eds), Advances in Pharmaceutical Sciences, Vol. 2. London, Academic Press, 181–221. , DANJO, K. and SUNADA, H. (1988) Measurement of the adhesive force between particles of powdered materials and a glass substrate by means of the impact separation method.

1992) Effect of geometry on particle adhesion. Aerosol. Sci. Tech. 17, 105–118. P. and ZOGRAFI, G. S. (1967) The flow properties of powders. H. E. (eds), Advances in Pharmaceutical Sciences, Vol. 2. London, Academic Press, 181–221. , DANJO, K. and SUNADA, H. (1988) Measurement of the adhesive force between particles of powdered materials and a glass substrate by means of the impact separation method. III. Effects of particle shape and surface asperity. Chem. Pharm. Bull. 36, 741–749. S. A. (1995) The adhesion and removal of particles from surfaces.

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Particulate Interactions in Dry Powder Formulations for Inhalation by Xian Ming Zeng


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