By Novartis Foundation, Novartis Foundation Symposium
Gramicidin channels were studied intensively for greater than 25 years. They serve as version shipping structures for big protein ion channels, because it is tough to glean high-resolution structural info at the latter.
This publication contains contributions from nearly the entire major scientists learning gramicidin channels and is the one compilation of labor during this box. It discusses crystallographic, spectroscopic, electrophysiological and computational stories, in particular within the gentle of the hot availability of high-resolution structural info, and it compares those with insights derived from higher structures. in addition to drawing jointly a lot new and fascinating paintings during this box, it presents tips that could promising new learn instructions.
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Extra info for Novartis Foundation Symposium 225 - Gramicidin and Related Ion Channel-Forming Peptides
ProcNatl Acad Sci USA 88:53455349 Nicholson LK, Moll F, Mixon TE, LoGrasso PV, Lay JC, Cross T A 1987 Solid-state I5NNMR of oriented lipid bilayer bound gramicidin A. Biochemistry 26:6621-6626 Pascal SM, Cross TA 1994 Polypeptide conformational space. Dynamics by solution NMR, disorder by X-ray crystallography. J Mol Biol241:431439 Sayle RA, Milner-White EJ 1995 RASMOL: biomolecular graphics for all. Trends Biochem Sci 20:374-376 Short KW, Wallace BA, Myers RA, Fodor SPA, Dunker AK 1987 Comparison of lipid/ gramicidin dispersions and cocrystals by Raman scattering.
Wallace: We only tried conditions similar to those you used for bacteriorhodopsin (Pebay-Peyroula et a1 1997), but we know that there are many variables so we should try some different conditions. Killian: It may not work in this system because gramicidin can induce nonlamellar structures and may not segregate out from a cubic phase to form crystals. References Burkhart BM, Gassman RM, Langs DA, Pangborn WA, Duax WL 1998 Heterodimer formation and crystal nucleation of gramicidin D. Biophys J 7521352146 Cuello LG, Romero JG, Cortes DM, Perozo E 1998 pH-dependent gating in the Streptomyces liuidans K+ channel.
Biol Membr (IJSSR) 3:1077-1104 Arseniev AS, Barsukov IL, Bystrov VF, Ovchinnikov YA 1986b Spatial structure ofgramicidin A transmembrane ion channel -NMR analysis in micelles. Biol Membr (USSR) 3:437462 22 DISCUSSION Barsukov IL, Lomize AL, Arseniev AS, Bystrov VF 1987 Spatial structure of succinylbis(desformy1)gramicidin A in micelles. NMR conformational analysis. Biol Membr (USSR) 4:171-193 Greathouse DV, Hatchett J, Jude AR, Koeppe RE, 11, Providence LL, Andersen 0s 1997 Neighboring aliphatic aromatic side chain interactions between residues 9 and 10 in gramicidin channels.
Novartis Foundation Symposium 225 - Gramicidin and Related Ion Channel-Forming Peptides by Novartis Foundation, Novartis Foundation Symposium