Download e-book for iPad: Neurotransmitter Transporters by Susan G. Amara (Eds.)

By Susan G. Amara (Eds.)

ISBN-10: 0076687929

ISBN-13: 9780076687923

ISBN-10: 0121821978

ISBN-13: 9780121821975

General Description of the Series:
Neurotransmitter Transporters specializes in biochemical, electrophysiological, pharmacological, molecular, and mobile organic techniques used to check neurotransmitter delivery structures. The articles offer precise descriptions of tactics that are supposed to let the reader to appreciate how they're entire and to copy or adapt them for his or her personal experimental wishes. This booklet is the 1st to target equipment which were the foundation for the quick improvement of this area.
General Description of the Series:
The severely acclaimed laboratory general for greater than 40 years, Methods in Enzymology is without doubt one of the so much hugely revered courses within the box of biochemistry. considering that 1955, each one quantity has been eagerly awaited, often consulted, and praised by means of researchers and reviewers alike. Now with greater than three hundred volumes (all of them nonetheless in print), the sequence comprises a lot fabric nonetheless correct today--truly a necessary ebook for researchers in all fields of existence sciences.

Key Features
* The delivery of CNS neurotransmitter transporters
* Electrophysiological, biochemical, molecular, mobile organic, pharmacological, neurochemical, and structural approaches
* either plasma and vesicular companies

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Additional resources for Neurotransmitter Transporters

Example text

F. Boron, A m . J. Physiol. 274, F425 (1998). _~ ° :F. ~o~ Z> >~ © © Z D 0 Z ~ ~ o= 0 r~ z < r~ © Z r ÷ ~a*6 '6 20 ~ ~ ~-~-~- ~= ~ ~ r~-~ :-=~ :~ . ~ ~ m ~ ~ 2] ~ 22 [21 PLASMA MEMBRANE CARRIERS TABLE II RECEPTOR c D N A s OBTAINED BY EXPRESSION CLONING USING OOCYTESa Receptor Tissue Organism Selection method Reference 5-HTlc serotonin receptor Choroidplexus tumor Stomach Choroid plexus Forebrain Brain Brain Adrenal medulla Lung SVll mouse VC 45 Bovine Rat Rat Rat Rat Bovine Guinea pig VC VC VC VC VC VC VC 46 63 47 30 31 48 49 VC VC VC 50 20 64 Substance K receptor 5-HTlc serotonin receptor Glutamate receptor Substance P receptor Neurotensin receptor Histamine H1 receptor Platelet-activating factor receptor Thrombin receptor Ca2+-sensing receptor ATP receptor HEL, Dami cells Human Parathyroid Bovine NG108-15 cells Mouse (neuroblastoma) a Receptor cDNA expression cloning typicaUy takes advantage of the normal transport mechanism inherent in the Xenopus oocyte.

A. Hediger, E. L. Boulpaep, and W. F. Boron, Nature 387, 409 (1997). 22b M. F. Romero, P. Fong, U. V. Berger, M. A. Hediger, and W. F. Boron, A m . J. Physiol. 274, F425 (1998). _~ ° :F. ~o~ Z> >~ © © Z D 0 Z ~ ~ o= 0 r~ z < r~ © Z r ÷ ~a*6 '6 20 ~ ~ ~-~-~- ~= ~ ~ r~-~ :-=~ :~ . ~ ~ m ~ ~ 2] ~ 22 [21 PLASMA MEMBRANE CARRIERS TABLE II RECEPTOR c D N A s OBTAINED BY EXPRESSION CLONING USING OOCYTESa Receptor Tissue Organism Selection method Reference 5-HTlc serotonin receptor Choroidplexus tumor Stomach Choroid plexus Forebrain Brain Brain Adrenal medulla Lung SVll mouse VC 45 Bovine Rat Rat Rat Rat Bovine Guinea pig VC VC VC VC VC VC VC 46 63 47 30 31 48 49 VC VC VC 50 20 64 Substance K receptor 5-HTlc serotonin receptor Glutamate receptor Substance P receptor Neurotensin receptor Histamine H1 receptor Platelet-activating factor receptor Thrombin receptor Ca2+-sensing receptor ATP receptor HEL, Dami cells Human Parathyroid Bovine NG108-15 cells Mouse (neuroblastoma) a Receptor cDNA expression cloning typicaUy takes advantage of the normal transport mechanism inherent in the Xenopus oocyte.

Schild, G. Buell, B. Thorens, I. Gautschi, J-D. Horisberger, and B. C. Rossier, Nature 367, 463 (1994). 18 G. Dai, O. Levy, and N. Carrasco, Nature 379, 458 (1996). 19 M. F. Romero, M. A. Hediger, E. L. Boulpaep, and W. F. Boron, F A S E B J. 10, A89 (1996). [2] EXPRESSION CLONING IN OOCYTES 19 Xenopus oocytes has also led to the identification of several receptor cDNAs (see Table II), an approach particularly popular when ligand binding produces an electrophysiological response. Selection of Organism and Tissue When designing a new expression cloning project, an important consideration is the source of tissue, and the organism (Fig.

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Neurotransmitter Transporters by Susan G. Amara (Eds.)


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