Download PDF by Chad A. Mirkin, Thomas J. Meade, Sarah Hurst Petrosko,: Nanotechnology-Based Precision Tools for the Detection and

By Chad A. Mirkin, Thomas J. Meade, Sarah Hurst Petrosko, Alexander H. Stegh

ISBN-10: 2272452752

ISBN-13: 9782272452756

ISBN-10: 3319165542

ISBN-13: 9783319165547

ISBN-10: 3319165550

ISBN-13: 9783319165554

This ebook discusses rising nanotechnology-based instruments that experience the capability to dramatically effect melanoma study, diagnostics, and therapy. melanoma is a fancy, devastating, and debilitating ailment and, even if a lot development has been made, novel, more suitable diagnostic and cures are nonetheless wanted, particularly for complex cancers. the last word target is to realize melanoma early and non-invasively and to supply efficacious and specific precision remedies that reason fewer destructive unwanted effects. This ebook explains how nanotechnology can take advantage of the size-, shape-, and composition-dependent houses of nanomaterials to supply novel instruments for precision melanoma medication. it is going to be of curiosity to researchers and pros operating within the fields of chemistry, biology, fabrics technological know-how and engineering, and medication who are looking to research extra approximately this attention-grabbing and fast moving quarter of research.

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Extra info for Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer

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Nature 501:338–345 4. Meacham CE, Morrison SJ (2013) Tumour heterogeneity and cancer cell plasticity. Nature 501:328–337 5. Briley WE, Halo TL, Randeria PS, Alhasan AH, Auyeung E, Hurst SJ, Mirkin CA (2012) Biochemistry and biomedical applications of spherical nucleic acids (SNAs). In: Nanomaterials for biomedicine. American Chemical Society, Washington, DC 6. Elsabahy M, Wooley KL (2012) Design of polymeric nanoparticles for biomedical delivery applications. Chem Soc Rev 41:2545–2561 7. Seferos DS, Giljohann DA, Hill HD, Prigodich AE, Mirkin CA (2007) Nano-flares: probes for transfection and mRNA detection in living cells.

1 SNA-Drug Conjugates for Drug Delivery ................................................................... 2 SNA-Antibody Conjugates for Cellular Targeting ...................................................... 3 Gadolinium-Enriched SNAs for Cellular Imaging....................................................... 4 Self-Assembled, Multimodal SNAs for Cancer Therapy ............................................ 5 Future Outlook.......................................................................................................................

Nature 430(6996):161–164 16. Hannon GJ (2002) RNA interference. Nature 418(6894):244–251 17. McManus MT, Sharp PA (2002) Gene silencing in mammals by small interfering RNAs. Nat Rev Genet 3(10):737–747 18. Zamore PD, Tuschl T, Sharp PA, Bartel DP (2000) RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101(1):25–33 19. Bartlett DW, Davis ME (2007) Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing.

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Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer by Chad A. Mirkin, Thomas J. Meade, Sarah Hurst Petrosko, Alexander H. Stegh


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