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These enzymes also are responsible for all or part of the metabolism and synthesis of a number of endogenous compounds, such as steroid hormones and prostaglandins. Though it was originally described as the CYP450 enzyme, it is now apparent that it is a group of related enzymes, each with its own substrate specificity. , CYP3A4, CYP2D6) have been identified as playing a role in human drug metabolism, and others may be discovered. 2. More than one CYP isoform may be involved in the metabolism of a particular drug.

These highly anionic structural components of the wall contribute to an electrostatic barrier and are most likely in the endothelial or glomerular basement membrane regions. Molecular configuration also may influence the rate of glomerular filtration of drugs. , dextrans). Thus, the efficient retention of proteins within the circulation is attributed to a combination of factors, including their globular structure, their large molecular size, and the magnitude of their negative charge. Factors that affect the glomerular filtration rate (GFR) also can influence the rate of drug clearance.

For a drug given orally, the primary site of drug absorption is: (A) The esophagus (B) The stomach (C) The upper portion of the small intestine (D) The large intestine 2. Patients can exhibit alterations in the rate and extent of drug absorption because of various factors. All of the following factors might affect the rate and/or extent of drug absorption EXCEPT: (A) Gastric emptying time (B) Intestinal motility (C) The presence of food (D) The formulation of the drug (E) A generic form of the drug 32 I GENERAL PRINCIPLES OF PHARMACOLOGY 3.

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Modern Pharmacology With Clinical Applications by various

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