By Michael Sand
Michael Sand provides the reader an outline of present recommendations in expression profiling of miRNAs and their maturation equipment within the pores and skin. This booklet is a postdoctoral thesis on miRNAs in cutaneous malignant cancer and non-melanoma epidermis melanoma with a spotlight at the miRNA processing equipment and miRNA expression profiling. The learn awarded during this booklet used to be played within the Dermatologic surgical procedure part on the division of Dermatology, Venereology and Allergology of the Ruhr-University Bochum, Germany and offers the reader an outline of present options in expression profiling of miRNAs and their maturation equipment within the skin.
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Extra info for MicroRNAs in malignant tumors of the skin: First steps of tiny players in the skin to a new world of genomic medicine
3-21). After semiquantitative analysis, an expression index (EI) was determined, which considered the intensity of the immunohistochemical coloring and the overall surface of positive reactions in the two-dimensional histological paraffin cross-section of the components studied. 05). 2 Examinations on malignant melanoma Tab. 3-4: 45 Expression data of the quantitative TaqMan RT-PCR of Dicer, Drosha, DGCR8, Exp-5, Argonaute-1, Argonaute-2, PACT, TARBP1 and TARBPT, MTDH, and SND-1 (average ± standard deviation) in primary cutaneous malignant melanoma (a = PCMM), cutaneous melanoma metastases (b = CMMM), and benign melanocytic nevi (c = BMN), * = significant difference.
In BCC, thehaswere 16has-regulatedhasRNAS (hsa-miR-17, hsamiR-18a, hsa-miR-18b, has-miR-19hashsa-miR-has-1*, hsa-miR-93, hsa-miR-106b, hsa-miR-1has-5p, hshasiR-130ahassa-miR-181hashsa© Springer Fachmedien Wiesbaden 2016 M. 1007/978-3-658-12794-7_4 54 4 Closing remarks miR-181c*, hsa-miR-181d, hsa-miR-182, hsa-miR-455-3p, hsa-miR-4555p and hsa-miR-542-5p) and 10 down-regulated (hsa-miR-29c, hsa-miR29c*, hsa-miR-139-5p, hsa-miR-140-3p, hsa-miR-145, hsa-miR-378, hsa-miR-572, hsa-miR-638, hsa-miR-2861, hsa-miR-3196) .
3-5), DGCR8 (Fig. 3-6), PACT (Fig. 3-6) and TARBP1 (Fig. 05; Tab. 3-2). The expression of TARBP2 (Fig. 05). 05). Argonaute proteins comprise the miRNA effector RISC. The overexpression of Argonaute-2 has already been demonstrated for squamous cell carcinoma in the head/throat area . Because there is an over-expression of Dicer in cSCC as a part of RISC, an increased expression of other RISC components, such as Argonaute-2, was to be expected. DGCR8 is, alongside Drosha, a main component of the microprocessor complex, which is essential for Drosha function and miRNA maturity.
MicroRNAs in malignant tumors of the skin: First steps of tiny players in the skin to a new world of genomic medicine by Michael Sand