Macromolecular Drug Delivery: Methods and Protocols by Mattias Belting PDF

By Mattias Belting

ISBN-10: 1588299996

ISBN-13: 9781588299994

ISBN-10: 159745429X

ISBN-13: 9781597454292

Macromolecular medicinal drugs carry the promise of turning into new therapeutics for numerous significant problems, together with melanoma and heart problems. This excellent power is explored in Macromolecular Drug supply, a quantity which provides a wide-ranging assessment of latest tools utilized in the sector, and which addresses the restrictions offered via an absence of secure and effective drug supply recommendations. Chapters supply info on either in vitro and in vivo equipment of macromolecular supply, hence attractive to a wide clinical viewers. Composed within the hugely profitable equipment in Molecular Biology™ sequence structure, each one bankruptcy encompasses a short creation, step by step equipment, an inventory of worthy fabrics, and a Notes part which stocks pointers on troubleshooting and heading off identified pitfalls.

Comprehensive and state of the art, Macromolecular Drug supply deals a platform for interdisciplinary collaboration, which may still offer possibilities for brand new discoveries on the interface among disciplines. eventually, this cooperation will bring about using macromolecular medicinal drugs as novel diagnostic instruments and, much more importantly, as a method to revolutionize the best way we view and deal with ailments.

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Current Pharmaceutical Design 10:2335–2343. D. (2006) Aptamer therapeutics advance. Current Opinion in Chemical Biology 10:282–289. A. (2005) Aptamers: an emerging class of therapeutics. Annual Review of Medicine 56:555–583. R. (2006) Discovery and development of anticancer aptamers. Molecular Cancer Therapeutics 5:2957–2962. S. et al. (2006) Tumor targeting by an aptamer. Journal of Nuclear Medicine 47:668–678. , and Missailidis, S. (2007) Radiolabelled aptamers for tumour imaging and therapy.

And Yu, H. (2006) Receptor-mediated gene delivery using polyethylenimine (PEI) coupled with polypeptides targeting FGF receptors on cells surface. Journal of Zhejiang University Science B 7:906–911. 28. , and Gu, J. (2002) Enhanced antitumor effect of EGF R-targeted p21WAF-1 and GM-CSF gene transfer in the established murine hepatoma by peritumoral injection. Cancer Gene Therapy 9: 100–108. 29. M. (2005) Vascular 26 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. Vorhies and Nemunaitis endothelial growth factor selectively targets boronated dendrimers to tumor vasculature.

11. W. (2006) Natural polymers for gene delivery and tissue engineering. Advanced Drug Delivery Reviews 58:487–499. 12. J. (2006) Sustained delivery of plasmid DNA from polymeric scaffolds for tissue engineering. Advanced Drug Delivery Reviews 58:500–514. 13. C. (2006) Synthetic and natural polycations for gene therapy: state of the art and new perspectives. Current Gene Therapy 6:59–71. Synthetic vs. Natural/Biodegradable Polymers 25 14. W. (2006) Current status of polymeric gene delivery systems.

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Macromolecular Drug Delivery: Methods and Protocols by Mattias Belting


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