Download e-book for kindle: Lead generation: methods, strategies, and case studies by Holenz, Jörg

By Holenz, Jörg

ISBN-10: 3527333290

ISBN-13: 9783527333295

ISBN-10: 3527677046

ISBN-13: 9783527677047

ISBN-10: 3527677054

ISBN-13: 9783527677054

ISBN-10: 3527677062

ISBN-13: 9783527677061

ISBN-10: 3527677070

ISBN-13: 9783527677078

During this finished two-volume source at the subject senior lead iteration medicinal chemists current a coherent view of the present equipment and methods in business and educational lead iteration. this can be the 1st booklet to mix either typical and leading edge ways in related breadth and intensity, together with numerous fresh winning lead new release case experiences released the following for the 1st time. Beginning Read more...

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the entire photo of tools and methods in commercial and educational lead discovering and optimization, overlaying average in addition to novel ways and highlighting their strengths and weaknesses. Read more...

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Additional info for Lead generation: methods, strategies, and case studies

Example text

It should be noted that some companies like Eli Lilly have tried to address this issue with their open innovation drug dis­ covery model that provides in-kind support for cutting-edge synthetic academic groups to test their novel scaffolds against a range of Eli Lilly screens [17]. 7 million compounds for collaborators to screen under confidential terms [18]. If successful, one would expect more of these types of in-kind collaborations to emerge, since they would help control the costs of exploring novel chemistry while at the same time ena­ bling access to the latest new synthetic methodologies.

Only if you have exhaustively tried and failed to find success in the drug-like space should you feel you have permission to go beyond it and then you will most definitely need not only all your skills but probably also a large slice of luck! Note that if we all choose to back the low odds scenario, that is, (2), all of the time, then we are indeed guaranteeing a poor return on investment. Lead Generation: Methods, Strategies, and Case Studies, First Edition. Edited by Jörg Holenz.  2016 Wiley-VCH Verlag GmbH & Co.

Quite often, the hit compounds arising from highthroughput screening (HTS) or any other hit-finding technology do not pro­ vide intrinsic SAR and gaps will need to be filled to see the entire picture. Before the data is even generated, lead criteria are established by the team in order to narrow down large hit lists into the most promising ones. Lead criteria are naturally less rigorous than the candidate selection criteria but will often reflect a front-loading of critical aspects of the project, for exam­ ple, by early focusing on selectivity versus off targets or addressing physico­ chemical liabilities like high lipophilicity already at the lead generation stage.

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Lead generation: methods, strategies, and case studies by Holenz, Jörg


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