Foye's Principles of Medicinal Chemistry (Lemke, Foye's - download pdf or read online

By David A. Williams PhD

ISBN-10: 0781768799

ISBN-13: 9780781768795

Acclaimed through scholars and teachers alike, Foye's ideas of Medicinal Chemistry is now in its 7th version, that includes up to date chapters plus new fabric that meets the desires of latest medicinal chemistry classes. This newest variation bargains an unprecedented presentation of drug discovery and pharmacodynamic brokers, integrating ideas of medicinal chemistry with pharmacology, pharmacokinetics, and scientific pharmacy.

All the chapters were written by means of a global group of revered researchers and academicians. cautious modifying guarantees thoroughness, a constant variety and structure, and simple navigation during the text.

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Additional info for Foye's Principles of Medicinal Chemistry (Lemke, Foye's Principles of Medicinal Chemistry)

Example text

A basic premise inherent in natural product drug discovery work is that the greater the degree of phylogenetic (taxonomic) diversity of the organisms sampled, the greater the resultant chemical diversity. Therefore, whereas natural product researchers tend to specialize in the types of organism on which they work, it is reasonable to envisage that the future investigation of all the major groups mentioned above will provide dividends in terms of affording new prototype biologically active compounds of use in drug discovery.

Several other natural product molecules or their derivatives have been shown to have a action similar to that of paclitaxel against tubulin and are now either in clinical trials or preclinical development; these include dictyostatin-1, eleutherobin, laulimalide, and sarcodictyin, all of which are marine origin (6,43,44,71). Also included in this group are discodermolide, a polyketide lactone from the marine sponge, Discodermia dissoluta, which has now been synthesized (71,72), and several epothilones from the terrestrial myxobacterium Sorangium cellulosum, of which epothilone B and its semisynthetic derivative ixabepilone are representative (Fig.

Butler MS. Natural products to drugs: natural product derived compounds in clinical trials. Nat Prod Rep 2005;22:162–195. 45. Cragg GM, Newman DJ. A tale of two tumor targets: topoisomerase I and tubulin. The Wall and Wani contribution to cancer chemotherapy. J Nat Prod 2004;67:232–244. 46. Ledizet M, Harrison LM, Koski RA, et al. Discovery and preclinical development of antithrombotics from hematophagous invertebrates. Curr Med Chem Cardiovasc Hematol Agents 2005;3:1–10. 47. Moen MD, Keating GM, Wellington K.

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Foye's Principles of Medicinal Chemistry (Lemke, Foye's Principles of Medicinal Chemistry) by David A. Williams PhD


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