By National Research Council (U. S.)
Deals file of the Workshop on improvement of a Polio Antiviral and its capability position in worldwide Poliomyelitis Eradication, held November 1-2, 2005. themes contain public well-being issues, capability organic goals of polio antiviral medicines, improvement of antiviral medicines for poliovirus, implementation, and extra. For researchers. Softcover.
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Extra resources for Exploring the Role of Antiviral Drugs in the Eradication of Polio: Workshop Report
As noted above, for the controlled clinical trial to be realistic for licensure, the “package insert” for the medication should be written before the clinical trial investigation. To that end, the primary use of a drug in treating poliovirus infections will be to prevent transmission from infected people to the susceptible individuals surrounding them. A potential secondary use would be to treat the very limited number of immunocompromised people who have been identified as chronic shedders of poliovirus.
As has been apparent in the development of drugs against many RNA viruses, the existence of a pool of variants makes it likely that mutants resistant to a given drug (“escape” mutants) already exist in the population before the drug is even used (Coffin 1995). The speed with which drug resistance will emerge is difficult to predict since it depends on the target chosen for inhibition and the circumstances in which the drug would be used. However, an ideal polio antiviral drug will have features that slow the emergence of resistant mutants.
1991). Precursor proteins such as 2BC and 3CDpro fulfill important functions in the replication cycle (see text). The mechanism of the maturation cleavage (filled triangle) is not understood. ) Copyright © National Academy of Sciences. All rights reserved. Copyright © National Academy of Sciences. All rights reserved. VP2 I VP3 2Apro catalyzed VP3 2A 2Apro *** 2A 2A 2A VP2 P1 * 2B 2BC 2B P2 VP1 Structural Region *** VP4 VP1 IRES II IIIIV V VI P1 3C/3CD pro catalyzed maturation cleavage VP4 VPO VPg FIGURE 3 Caption on previous page.
Exploring the Role of Antiviral Drugs in the Eradication of Polio: Workshop Report by National Research Council (U. S.)