Epilepsy: Mechanisms, Models, and Translational Perspectives by Jong Rho, Raman Sankar, Carl E. Stafstrom PDF

By Jong Rho, Raman Sankar, Carl E. Stafstrom

ISBN-10: 142008559X

ISBN-13: 9781420085594

Epilepsy has troubled humankind all through recorded heritage; but, it is just within the final half-century, that major growth has been made in our simple realizing of the epileptic mind. Pivotal advances in drug improvement and surgical ideas, in addition to the emergence of leading edge ways equivalent to electric stimulation of the worried approach, have ended in a considerable relief within the morbidity and mortality of sufferers with epilepsy. even as, awesome advancements in neuroscience have more desirable our realizing of mind constitution and function.

Epilepsy: Mechanisms, types, and Translational views accommodates new translational advances that carry epilepsy cures from the laboratory bench to the bedside and again back. It brings jointly the paintings of greater than 70 of the field’s most precious and state of the art researchers and clinicians. In 24 chapters, this terribly entire and present work:

Offers an outline of the elemental anatomic and sensible substrates of seizure genesis and considers novel pathogenic ideas that experience either emerged and been established experimentally
— Examines antiepileptic drug remedy, together with the most recent on molecular targets
— appears to be like on the nation of surgical remedies for epilepsy and discusses advances within the fields of structural and practical neuroimaging
— studies the range of nontraditional healing techniques, comparable to the ketogenic nutrition, the vagus nerve stimulator, immunomodulators, neurosteroids, herbs, and botanicals
— Investigates neuroendocrine, hormonal, and biobehavioral elements that effect seizure susceptibility—information that may be integrated into the layout of remedy algorithms on an individualized basis
— offers a glimpse of what destiny epilepsy cures may perhaps appear like, from novel mechanisms of drug supply to gene and stem-cell remedies for epilepsy to seizure detection tools, to the last word target of disorder prevention.

The concept for this e-book used to be encouraged via the editors’ collective wish to advertise bridging of the so-called translational divide—that is, masking cutting edge remedy ideas in response to medical rules that experience but to be verified carefully within the medical environment, yet but could provide practitioners with new and promising techniques towards epilepsy therapeutics.

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Extra resources for Epilepsy: Mechanisms, Models, and Translational Perspectives

Example text

Finally, GABAB receptors are involved in mediating long-lasting thalamic IPSPs involved in the generation of normal thalamocortical rhythms, whereas brainstem monoaminergic projections disrupt these rhythms. Thus, absence seizures appear to result from the combined dysfunction of T-type calcium channels, HCN channels, and GABAB receptors, as well as other pathophysiological mechanisms. 16 Epilepsy: Mechanisms, Models, and Translational Perspectives Increased Seizure Susceptibility of the Immature Brain Seizure incidence is highest during the first decade and especially during the first year of life (Hauser, 1994).

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J. , 85:1719–1731. , A. Ahidouch, H. Sevestre, P. Merviel, Y. El Hiani, M. Robbe, H. Ouadid-Ahidouch. (2008). Expression of K+ channels in normal and cancerous human breast. Histol. , 23:965–972. A. M. Y. T. B. J. Benos. (1999). Malignant human gliomas express an amiloride-sensitive Na+ conductance. Am. J. , 276:C1405–C1410. L. Y. M. M. B. J. Benos. (2004). Cation selectivity and inhibition of malignant glioma Na+ channels by psalmotoxin 1. Am. J. Physiol. , 287(5):C1282–C1291. , S. Weyers, T. Postert, R.

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Epilepsy: Mechanisms, Models, and Translational Perspectives by Jong Rho, Raman Sankar, Carl E. Stafstrom


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