New PDF release: Drug Discovery: A Casebook and Analysis

By Robert A. Maxwell

ISBN-10: 1461204690

ISBN-13: 9781461204695

ISBN-10: 1461267757

ISBN-13: 9781461267751

This treatise had its origins within the authors' powerful opinion that the invention of latest medicinal drugs, specifically of leading edge healing brokers, particularly doesn't ensue as a spontaneous sequel to investiga­ tive learn, irrespective of how penetrating such examine might be. relatively, it appeared to us that the invention of cutting edge healing brokers used to be a truly lively method, present in and of itself, and important complete attention-it was once no longer easily a passive, based by-process of investigative learn. And but, many researchers­ a few shut confreres of the authors, others extra distant-believed another way. We felt that their view mirrored unrealistic considering and that truth most likely lay in the direction of what Beyer" maintained: we're taught to think that if we will be able to comprehend a ailment it's going to be effortless adequate to determine, say, the molecular configuration of a definitive receptor mechanism someplace alongside the road and to layout a selected drug . . . . And so we begin out to appreciate the sickness yet by no means get round to doing a lot approximately treatment. The authors very quickly learned that there has been primarily no quantitive details to be had on simply the place and the way leading edge healing brokers have been came across. there have been in basic terms anecdotal debts, and those have been in a position to be chosen and offered in ways in which will be used to shield any aspect of view.

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Additional info for Drug Discovery: A Casebook and Analysis

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Keirn, H. , Weber,M. , Sealey, J. , and Laragh, J. : Possible role of renin in hypertension as suggested by renin-sodium profiling and inhibition of converting enzyme. N. Engl. J. Med. 296: 641-646,1977. Case, D. , Wallace, J. , Weber, M. 1. , Sealey, J. , and Laragh, J. H: Estimating renin participation in hypertension. Superiority of converting enzyme inhibitor over Saralasin. Am. J. Med. 61: 790-796, 1976. Cohn, J. N. and Levine, T. : Angiotensin-converting enzyme inhibition in congestive heart failure: The concept.

Dickinson, C. , Domhorst, A. , Green, K. , Hill, 1. , Laurance, D. , Prichard, B. N. , Robinson, B. and Rosenheim, M. : Effect of pronethalol in angina pectoris. Br. Med. J. 2: 1226,1227, 1963. Ariens, E. : Mfinity and intrinsic activity in the theory of competitive inhibition. Part 1. Problems and theory. Arch. Int. Pharrnacodyn. 99: 32-49, 1954. Bennett, D. R, ed. , American Medical Association, Chicago, 1983. :MerckManual, Merck Sharp & Dohme Research Laboratories, Rahway, NJ, 1982. J3-Blocker Heart Attack Trial Research Group: A randomized trial of propranolol in patients with acute myocardial infarction: 1.

R. W. and Padfield, P. : Angiotensin-convertingenzyme inhibitors: Past, present, and bright future. Lancet 1: 30-34, 1985. Engel, S. , Schaeffer, T. , Gold, B. : Inhibition of pressor effects of angiotensin I and augmentation of depressor effects of bradykinin by synthetic peptides. Proc. Soc. Exp. BioI. Med. 140: 240-244, 1972. Engel, S. , Schaeffer, T. , Waugh, M. : Effects of the nonapeptide SQ 20,881 on blood pressure of rats with experimental renovascular hypertension. Proc. Soc. Exp. BioI.

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Drug Discovery: A Casebook and Analysis by Robert A. Maxwell

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