By Ivana Pantelic
The on-going ‘green’ development within the own care coupled with international environmental matters, position natural-origin, biodegradable and skin-friendly surfactants equivalent to alkyl polyglucosides (APGs) in excessive call for. After winning use in cosmetics, enough facts has been acquired to welcome a few sugar emulsifiers into the sphere of drug dosage. Alkyl Polyglucosides offers a accomplished compendium which courses a researcher from the APG-related preformulation phases to formula processing, together with the research of assorted APG-stabilized platforms pores and skin functionality. This publication introduces quite a few APG representatives, their advantages relating to sure traditional surfactants, physicochemical and interfacial homes, attainable interplay with favourite parts and various characterization innovations vital for the review of colloidal platforms. the 1st bankruptcy introduces alkyl polyglucosides, through chapters on their homes, behaviour, an summary of the patent defense mechanisms and directions for filing patent purposes. ultimately, a end surveys overseas patent functions concerning APGs.
- introduces the sphere of alkyl polyglucoside emulsifiers, directory all of the modern and newly synthesized APG emulsifiers
- provides distinctive details on a number of elements of APG-based buildings
- reveals power of APG-stabilized autos as potential supply platforms utilizing a number of version medications and beauty actives
- includes an updated evaluate of study performed within the box of APGs, facilitating destiny preformulation and formula reviews for researchers
- offers a concise and sensible compendium of characterization thoughts
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Extra resources for Alkyl polyglucosides : from natural-origin surfactants to prospective delivery systems
2011). Aqueous and lipid phases were prepared separately. Solid lipid was melted at 75 °C to prevent the recrystallization of lipids during the process. Hydrophilic surfactants and water were heated to the same temperature and added to the melted lipid phase. The mixture was dispersed with a high-shear mixer (Ultra Turrax, IKA Staufen, Germany) for 30 s at 8000 rpm and subjected to high-pressure homogenization, applying a pressure of 500 bar. The homogenizer (Micron LAB 40, APV Deutschland GmbH, Germany) was equipped with a water jacket for temperature control.
Colloids Surf A Physicochem Eng Asp 2009; 339: 48–59. Jaksic I, Lukic M, Malenovic A, Reichl S, Hoffmann C, et al. Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization – A ketoprofen case study. Eur J Pharm Biopharm 2012; 80:162–75. Johansson I, Svensson M. Surfactants based on fatty acids and other natural hydrophobes. Curr Opin Colloid Interface Sci 2001; 6: 178–88. 49 Alkyl Polyglucosides Junginger HE.
2011). , 2005b). It was postulated that this molecule, belonging to the group of amphiphile glucolipids, could form both the thermotropic liquid crystalline phases in their pure state upon heating and the lyotropic liquid crystalline phases upon addition of a solvent (Stubenrauch, 2001). At that time there was a lack of comprehensive data on mesomorphic behaviour of long-alkyl-chain glycosides, combined with fatty alcohols, in the form of well-known mixed emulsifiers. , 2005b) assessing a series of binary (emulsifier/water) and ternary systems (emulsifier/water/oil) prepared using fixed ratios of components and medium-chain triglycerides as the oil phase.
Alkyl polyglucosides : from natural-origin surfactants to prospective delivery systems by Ivana Pantelic